Fragile X mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. circRNA biogenesis competes with pre-mRNA splicing. The noncoding RNA revolution: trashing old rules to forge new ones. U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation. U1 snRNP determines mRNA length and regulates isoform expression. Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Promoter proximal splice sites enhance transcription. A 5′ splice site enhances the recruitment of basal transcription initiation factors in vivo. Pre-mRNA processing reaches back to transcription and ahead to translation. RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.
Non-coding-RNA regulators of RNA polymerase II transcription. Targeting nuclear RNA for in vivo correction of myotonic dystrophy. Short intronic repeat sequences facilitate circular RNA production.
Complementary sequence-mediated exon circularization. Inverted repeats are necessary for circularization of the mouse testis Sry transcript. Circular RNAs are abundant, conserved, and associated with ALU repeats. Expanded identification and characterization of mammalian circular RNAs. Natural RNA circles function as efficient microRNA sponges. Circular RNAs are a large class of animal RNAs with regulatory potency. Cell-type specific features of circular RNA expression. Salzman, J., Chen, R.E., Olsen, M.N., Wang, P.L. Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing. Bioinformatic analysis of exon repetition, exon scrambling and trans-splicing in humans. A genome-wide survey demonstrates widespread non-linear mRNA in expressed sequences from multiple species. Circular transcripts of the testis: determining gene Sry in adult mouse testis. Splicing with inverted order of exons occurs proximal to large introns. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells.
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis. Modulation of chromatin modifying complexes by noncoding RNAs in trans. SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. U1 snRNA associates with TFIIH and regulates transcriptional initiation. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation. Non-coding RNA: a new frontier in regulatory biology. Environmental RNA interference in animals. Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. Signals from noncoding RNAs: unconventional roles for conventional pol III transcripts. lincRNAs: genomics, evolution, and mechanisms. RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. Epigenetic regulation by long noncoding RNAs.
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